130855-56-0

Usage

Uses

Used in Pharmaceutical Synthesis:
α-Me-Phe(3-F)-OH is used as a building block in the synthesis of peptide therapeutics and pharmaceuticals for its ability to modulate biological activity and improve drug-like properties.
Used in Drug Development:
α-Me-Phe(3-F)-OH is utilized in the development of new drugs for various medical conditions due to its potential to enhance pharmacological properties and bioavailability.

Upstream product

• 456-42-8 m-fluorobenzyl chloride 

Downstream Products

• 183478-98-0 N-acetyl-1-(3-fluorophenyl)-2-methyl-2-(2-thiazolyl)ethylamine 
• 183478-94-6 (S)-2-Acetylamino-3-(3-fluoro-phenyl)-2-methyl-propionamide 
• 183478-96-8 N-[(S)-2-(3-Fluoro-phenyl)-1-methyl-1-thiocarbamoyl-ethyl]-acetamide 
• 183478-92-4 (S)-4-(3-Fluoro-benzyl)-2,4-dimethyl-4H-oxazol-5-one 
• 183478-91-3 N-[(S)-1-Cyano-2-(3-fluoro-phenyl)-1-methyl-ethyl]-acetamide 
• 183478-90-2 (S)-2-Acetylamino-3-(3-fluoro-phenyl)-2-methyl-propionic acid 

Relevant academic research and scientific papers

A new approach to the efficient method for the asymmetric synthesis of (S)-O-, M-, P-fluorophenylalanines and their 2-methyl-substituted analogs

The reactions of asymmetric C-alkylation of glycine and alanine in NiII complexes of their Schiff's bases with modified chiral auxiliaries (S)-2-N-[(N0-2-chlorobenzylprolyl)- amino]benzophenone and (S)-2-N-[N′-(3, 4-dimethylbenzylprolyl)amino]benzophenone by fluorine-substituted benzyl halogenides have been studied. As a result, a highly stereoselective and relatively rapid method for the asymmetric synthesis of (S)-o-, m-, p-fluorophenylalanines and their 2-methyl substituted analogs has been developed.

Enantioselective synthesis of α,α-disubstituted amino acid derivatives via enzymatic resolution: Preparation of a thiazolyl-substituted α-methyl α-benzyl amine

A new and efficient enantioselective synthesis of the (S)-α,α-disubstituted phenethylamine 1 via Lipase resolution of the esters 3 and 4 is described. The effect of pH, enzyme load, and solubilizing additives has been studied and optimized. Conversion of the carboxylic acid 10 to the desired thiazole 1 is accomplished in high overall yield via an intermediate oxazolinone 13. This facile process requires only a single chromatographic step, and multigram quantities of 1 have been prepared.

Asymmetric synthesis of organoelement analogues of natural products; Part 12: General method for the asymmetric synthesis of fluorine-containing phenylalanines and α-methyl(phenyl)alanines via alkylation of the chiral nickel(II) Schiff's base complexes of

Nickel(II) complexes of Schiff's bases derived from (S)-o-[(N-benzyl]prolyl)amino]benzophenone [N-(2-benzoylphenyl)-1-benzylpyrrolidine-2-carboxamide] (BBP) and glycine or alanine have been used for asymmetric synthesis of fluoro (S)-phenylalanines and (S