130867-89-9

Upstream product

• 130867-72-0 5-Amino-1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-3-phenyl-1H-pyrazole-4-carbonitrile 
• 122-51-0 orthoformic acid triethyl ester 
• 23737-51-1 solketal tosylate 
• 42754-61-0 5-amino-3-phenyl-1H-pyrazole-4-carbonitrile 
• 42754-69-8 4-Amino-3-phenylpyrazolo<3,4-d>pyrimidine 

Downstream Products

• 131212-19-6 3-(4-Amino-3-phenyl-pyrazolo[3,4-d]pyrimidin-1-yl)-propane-1,2-diol; hydrochloride 

Relevant academic research and scientific papers

Synthesis of some 1-(dihydroxypropyl)pyrazolo-pyrimidines and in vivo evaluation of their antileishmanial and antitrypanosomal activity

A number of 1-(2,3-dihydroxypropyl)- and 1-pyrazolopyrimidines were synthesized.Some of these compounds were evaluated for their activity against Leishmania infantum and Trypanosoma brucei brucei in mice.The highest degree of antileishmanial activity was displayed by the 4-amino-1-(RS)-(2,3-dihydroxypropylpyrazolopyrimidine 11a, which yielded a 87percent and 96percent parasite inhibition in a standard 5-day test and in a long-term (14 days) treatment, respectively, though full cures of animals were not achieved.On the contrary, thisderivative did not significantly prolong the survival of T b brucei infected mice.