130906-76-2

Upstream product

• 101018-33-1 1-phenyl-1-p-tolyl-allyl alcohol 
• 32046-97-2 1-p-methylphenyl-3-phenyl-2,3-epoxy-1-propanone 
• 101109-89-1 3-oxo-2-phenyl-3-(4-methylphenyl)propanal 
• 4224-96-8 3-phenyl-1-p-tolylprop-2-en-1-one 

Relevant academic research and scientific papers

Organoiodine-induced hydroxylation as well as enantioselective alkoxylation/hydroxylation of allylic alcohols via 1,2- aryl migration

A new method for the hydroxylation of allylic alcohols using [hydroxyl(tosyloxy)iodo]benzene (HTIB) as both oxidant and reagent has been developed. Meanwhile, the enantioselective alkyoxylation as well as hydroxylation catalyzed by simple chiral iodine be

Metal-free, one-pot, sequential protocol for transforming ,-epoxy ketones to -hydroxy ketones and -methylene ketones

A new sequential, one-pot protocol for transforming 1,3-disubstituted 2,3-epoxy ketones to β;-hydroxy ketones and α-methylene ketones has been developed. Reaction of epoxy ketones with boron trifluoride etherate (BF3·OEt2) generates the cationic intermediates by regioselective epoxide ring opening and an acyl shift. Then, a treatment of these cations with 2-aryl-1,3-dimethylbenzimidazolines (DMBIH) results in formation of 1,2-disubstituted 3-hydroxy ketones. DMBIH serves as a hydride donor in the second step of this process. Finally, the β;-hydroxy ketones can be converted to 1,2-disubstituted 2-methylene ketones by treatment with methanesulfonic acid or a combination of methanesulfonyl chloride and triethylamine. Importantly, the sequential steps involved in formation of the α-methylene ketone products can be carried out in one pot.