1309060-53-4Relevant articles and documents
Imidazol-1-ylethylindazole voltage-gated sodium channel ligands are neuroprotective during optic neuritis in a mouse model of multiple sclerosis
Browne, Lorcan,Lidster, Katie,Al-Izki, Sarah,Clutterbuck, Lisa,Posada, Cristina,Chan, A. W. Edith,Riddall, Dieter,Garthwaite, John,Baker, David,Selwood, David L.
, p. 2942 - 2952 (2014/05/06)
A series of imidazol-1-ylethylindazole sodium channel ligands were developed and optimized for sodium channel inhibition and in vitro neuroprotective activity the molecules exhibited displacement of a radiolabeled sodium channel ligand and selectivity for blockade of the inactivated state of cloned neuronal Nav channels. Metabolically stable analogue 6 was able to protect retinal ganglion cells during optic neuritis in a mouse model of multiple sclerosis.