130930-42-6

Basic information

• Product Name: Cyclopropanecarboxylic acid, 1-amino-2,2-dimethyl-, (1S)- (9CI)
• Synonyms: Cyclopropanecarboxylic acid, 1-amino-2,2-dimethyl-, (1S)- (9CI)
• CAS NO: 130930-42-6
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.15704
• Product Categories: AMINOACID;CARBOXYLICACID
• Mol File: 130930-42-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclopropanecarboxylic acid, 1-amino-2,2-dimethyl-, (1S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanecarboxylic acid, 1-amino-2,2-dimethyl-, (1S)- (9CI)(130930-42-6)
• EPA Substance Registry System: Cyclopropanecarboxylic acid, 1-amino-2,2-dimethyl-, (1S)- (9CI)(130930-42-6)

Safety Data

• Hazardous Substances Data: 130930-42-6(Hazardous Substances Data)

Upstream product

• 130832-64-3 Ethyl 2,2-dimethyl-1-formylaminocyclopropane-1-carboxylic acid 
• 130832-63-2 1-Formylamino-2,2-dimethyl-cyclopropanecarboxylic acid ethyl ester 
• 42303-22-0 ethyl 2-isocyano-3-methyl-2-butenoate 
• 130832-62-1 1-Isocyano-2,2-dimethyl-cyclopropanecarboxylic acid ethyl ester 
• 152982-56-4 (3S,5S)-4-Benzoyl-5-tert-butyl-1,1-dimethyl-6-oxa-4-aza-spiro[2.4]heptan-7-one 
• 130930-41-5 (-)-Ethyl 2,2-dimethyl-1-formylaminocyclopropane-1-carboxylic acid 

Relevant articles and documents

Synthesis of (1S)-1-amino-2,2-dimethylcyclopropane-1-carboxylic acid via PLE mediated hydrolysis of bis(2,2,2-trifluoroethyl) 2,2-dimethylcyclopropane-1,1-dicarboxylate

Hydrolysis of bis(2,2,2-trifluoroethyl) 2,2-dimethylcyclopropane-1,1-dicarboxylate with pig liver esterase afforded (1R)-2,2-dimethyl-1-(2,2,2-trifluoroethoxycarbonyl)-cyclopropane-1-carboxylic acid in high enantiomeric excess. This compound was rearranged to (1S)-2,2,2-trifluoroethyl-2,2-dimethyl-1-[(N-ethoxycarbonyl)amino]- cyclopropane-1-carboxylate via a Curtius type reaction with DPPA. Final alkaline hydrolysis gave (1S)-1-amino-2,2-dimethylcyclopropane-1-carboxylic acid.

Simple Synthesis of (-)-(S)- and (+)-(R)-2,2-Dimethyl-1-aminocyclopropane-1-carboxylic Acid (2,2-Dimethyl-ACC)

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