1309362-71-7Relevant academic research and scientific papers
A general copper powder-catalyzed ullmann-type reaction of 3-halo-4(1 H)-quinolones with various nitrogen-containing nucleophiles
Audisio, Davide,Messaoudi, Samir,Peyrat, Jean-Francois,Brion, Jean-Daniel,Alami, Mouad
, p. 4995 - 5005 (2011)
3-(N-Substituted) 4(1H)-quinolinones were synthesized using the copper-catalyzed Ullmann C-N bond forming strategy in moderate to quantitative yields. Starting from 3-halo-4(1H)-quinolones, various nucleophiles including amides, lactams, sulfonamides and NH-containing azoles have been used successfully. In all cases, the reactions take place rapidly in toluene and proceed by using copper powder as a catalyst, DMEDA as a ligand and K 2CO3 as a base. In addition, other related heterocycles such as 3-bromoquinolin-2(1H)-ones, 3-bromocoumarin, and 3,5-dibromo-2-pyridone show good to very high reactivity with various nucleophiles under our Cu/DMEDA catalyst system.
