1309435-06-0Relevant academic research and scientific papers
Sulfoxide-alkene hybrids: A new class of chiral ligands for the Hayashi-Miyaura reaction
Thaler, Tobias,Guo, Li-Na,Steib, Andreas K.,Raducan, Mihai,Karaghiosoff, Konstantin,Mayer, Peter,Knochel, Paul
, p. 3182 - 3185 (2011/08/06)
Sulfoxide-alkene hybrids are introduced as a new class of chiral heterodentate ligands for the Hayashi-Miyaura reaction. The synthesis of these ligands was achieved without the use of protecting groups. A chiral resolution was performed via simple column-chromatographic separation of the diastereomeric ligands. Both diastereomers proved to be excellent ligands in Rh-catalyzed 1,4-addition reactions, furnishing chiral products with high enantioselectivities and, remarkably, opposite stereoconfigurations.
