1309455-68-2

Upstream product

• 104132-79-8 2-(4-chlorophenyl)-2-oxoacetyl chloride 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 1268021-55-1 2-(4-chlorophenyl)-2-oxo-N-phenylacetamide 

Downstream Products

• 1309455-79-5 3-(4-chlorophenyl)-3-hydroxy-4-methylene-1-phenylpyrrolidin-2-one 

Relevant academic research and scientific papers

Nickel-catalyzed intramolecular nucleophilic addition of aryl or vinyl chlorides to α-ketoamides through C-Cl bond activation

Nickeleophilic addition! The first example of a nickel-catalyzed direct intramolecular nucleophilic addition of aryl or vinyl chlorides to α-ketoamides through C-Cl bond activation is reported, which takes place under mild reaction conditions (see scheme).