1309455-77-3

Upstream product

• 159388-45-1 N-methyl-2-oxo-N,4-diphenylbutanamide 
• 76-05-1 trifluoroacetic acid 
• 2058-74-4 1-methyl-1H-indole-2,3-dione 
• 536-74-3 phenylacetylene 
• 1172590-86-1 3-hydroxy-1-methyl-3-(phenylethynyl)-1,3-dihydro-2H-indol-2-one 
• 710-11-2 2-oxo-4-phenylbutyric acid 
• 1309455-62-6 N-(2-chlorophenyl)-N-methyl-2-oxo-4-phenylbutanamide 

Relevant academic research and scientific papers

Trifluoroacetic acid-promoted synthesis of 3-hydroxy, 3-amino and spirooxindoles from α-keto-N-anilides

Ketoanilides containing alkyl side chains were readily cyclized to 3-hydroxy-2-oxindoles or spirooxindoles by a single or double intramolecular Friedel-Crafts reaction in the presence of trifluoroacetic acid (TFA) at room temperature or at 45 °C. α-Iminoc

Nickel-catalyzed intramolecular nucleophilic addition of aryl or vinyl chlorides to α-ketoamides through C-Cl bond activation

Nickeleophilic addition! The first example of a nickel-catalyzed direct intramolecular nucleophilic addition of aryl or vinyl chlorides to α-ketoamides through C-Cl bond activation is reported, which takes place under mild reaction conditions (see scheme).