1309469-18-8

Basic information

• Product Name: C₁₉H₂₅N₅O₃S
• CAS NO: 1309469-18-8
• Molecular Weight: 403.505
• Mol File: 1309469-18-8.mol

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₅N₅O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₅N₅O₃S(1309469-18-8)
• EPA Substance Registry System: C₁₉H₂₅N₅O₃S(1309469-18-8)

Safety Data

• Hazardous Substances Data: 1309469-18-8(Hazardous Substances Data)

Upstream product

• 1309469-14-4 C₂₄H₃₃N₅O₅S 
• 58722-35-3 1-[4-(morpholine-4-sulfonyl)phenyl]ethan-1-one 
• 1042947-72-7 C₁₅H₂₀N₂O₄S 

Downstream Products

• 1309469-46-2 C₂₀H₂₇N₅O₃S 
• 1309469-45-1 C₁₉H₂₆N₆O₅S₂ 
• 1309469-44-0 C₂₀H₂₇N₅O₅S₂ 

Relevant articles and documents

Discovery of piperidinyl aminopyrimidine derivatives as IKK-2 inhibitors

A serine-threonine kinase IKK-2 plays an important role in activation of NF-κB through phosphorylation of the inhibitor of NF-κB (IκB). As NF-κB is a major transcription factor that regulates genes responsible for cell proliferation and inflammation, development of selective IKK-2 inhibitors has been an important area of anti-inflammatory and anti-cancer research. In this study, to obtain active and selective IKK-2 inhibitors, various substituents were introduced to a piperidinyl aminopyrimidine core structure. The structure-activity relationship study indicated that hydrogen, methanesulfonyl, and aminosulfonyl groups substituted at the piperidinylamino functionality provide high inhibitory activity against IKK-2. Also, morpholinosulfonyl and piperazinosulfonyl group substituted at the aromatic ring attached to the aminopyrimidine core significantly increased the inhibitory activity of the resulting derivatives. In particular, compound 17 with the aromatic piperazinosulfonyl substituent showed the most potent (IC50 = 1.30 μM) and selective (over other kinases such as p38α, p38β, JNK1, JNK2, JNK3, and IKK-1) inhibitory activity against IKK-2.