1309474-99-4

Upstream product

• 928134-65-0 (+)-(R)-4-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile 

Downstream Products

• 1309475-54-4 (R)-4-(6,6-dimethyl-7-oxo-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluoro-benzonitrile 
• 1309475-06-6 3-fluoro-4-((5R,7S)-7-hydroxy-7-(4-(trifluoromethoxy)phenyl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)benzonitrile 
• 1309475-53-3 4-((5R,7S)-7-(cyclopropylethynyl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluoro-benzonitrile 
• 1309475-02-2 3-fluoro-4-((5R,7S)-7-hydroxy-7-vinyl-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)benzonitrile 
• 1309475-07-7 4-((5R,7R)-7-(benzo[d]thiazol-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluoro-benzonitrile 
• 1309475-05-5 4-((5R,7S)-7-(3,4-dimethyl-phenyl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluoro-benzonitrile 
• 1309475-99-7 tert-butyl 2-((5R,7S)-5-(4-cyano-2-fluorophenyl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)acetate 
• 1309475-03-3 4-((5R,7S)-7-(3-cyclopropyl-phenyl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluoro-benzonitrile 
• 1309475-61-3 3-fluoro-4-((5R)-7-hydroxy-7-(3-(tetrahydro-2H-pyran-2-yloxy)phenyl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)benzonitrile 
• 1309475-04-4 4-((5R,7S)-7-(4-(1,1-difluoro-ethyl)-phenyl)-7-hydroxy-6,7-dihydro-pyrrolo[1,2-c]imidazol-5-yl)-3-fluoro-benzonitrile 
• 1309475-64-6 3-fluoro-4-((5R,7S)-7-hydroxy-7-(3-(pyrimidin-2-yl)phenyl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)benzonitrile 
• 1309475-65-7 3-fluoro-4-((5R,7S)-7-hydroxy-7-(3-(pyridin-3-yl)phenyl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)benzonitrile 
• 1309475-62-4 3-fluoro-4-((5R,7S)-7-hydroxy-7-(3-hydroxyphenyl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)benzonitrile 
• 1309475-63-5 3-((5R,7S)-5-(4-cyano-2-fluorophenyl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)phenyl triftuoromethanesulfonate 

Relevant academic research and scientific papers

IMIDAZOLE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS

The present invention provides a compound of formula (I) or pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, R7 and p are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.