130948-71-9Relevant academic research and scientific papers
Facile solid-phase synthesis of cycloalkylphosphonates and 1-cycloalkenylphosphonates using polymer-supported phenylsulfonylmethylphosphonates
Liu, Xiao-Ling,Sheng, Shou-Ri,Zhou, Wei,Wang, Qin-Ying,Zhang, Xiao-Lan,Gong, Bin
, p. 119 - 127 (2007)
A facile procedure for the solid-phase synthesis of cycloalkylphosphonates and 1-cycloalkenylphosphonates in good yields and high purities using polystyrene-supported phenylsulfonylmethylphosphonates with traceless sulfone linker strategy is described. Copyright Taylor & Francis Group, LLC.
Convenient synthesis of cycloalkylphosphonates from (Phenylsulfonyl)methylphosphonate
Kim, Dae Young,Suh, Ki Hyung
, p. 83 - 91 (2007/10/03)
Cycloalkylphosphonate derivatives were synthesized in excellent overall yields, in two steps by the bis-alkylation of (phenyl sulfonyl)methylphosphonate with ω-dibromoalkanes in the presence of a phase transfer catalyst followed by desulfonation.
α-FUNCTIONAL CYCLOALKYLPHOSPHONATES. I. SYNTHESIS
Nasser, Jamal,About-Jaudet, Elie,Collignon, Noel
, p. 171 - 179 (2007/10/02)
Cycloalkylphosphonates 2 of different sizes (from cyclopropyl to cycloheptyl) bearing various functional groups Z in α-position were synthesized by bis-alkylation of α-functional methylphosphonates 1 and ω-dibromoalkanes in presence of base.The choice of the basic system is determined by the nature of Z.With powerful electron-withdrawing groups, NaH-THF/DMSO (Method A, for Z = CN, SO2R) or liquid-solid phase transfer process proved to be the more suitable systems.For Z = aryl or SR, lithium diisopropylamide is required to achieve the deprotonation.A wide range of new phoshonates were obtained in high yields on preparative scale.
