1309565-74-9

Upstream product

• 941-55-9 4-toluenesulfonyl azide 
• 1309565-90-9 1-(cyclopropylidenemethyl)-2-ethynyl-4-fluorobenzene 
• 749874-24-6 2-ethynyl-4-fluorobenzaldehyde 
• 2561-17-3 1-ethynyl-3-fluoro-benzene 
• 98-59-9 p-toluenesulfonyl chloride 
• 6367-75-5 2-(tosylamino)ethyl p-toluenesulfonate 
• 3634-89-7 N-(p-toluenesulfonyl)aziridine 
• 813414-83-4 1-bromo-2-(meta-fluorophenyl)ethyne 

Relevant academic research and scientific papers

Dual Gold-Catalyzed Formal Tetradehydro-Diels–Alder Reactions for the Synthesis of Carbazoles and Indolines

This work reports a dual gold-catalyzed tetradehydro-Diels–Alder reaction for the synthesis of nitrogen-containing aromatic heterocycles. Under the catalytic system (IPrAuNTf2/DIPEA), indolines and carbazoles as well as other N-containing aromatic heterocycles were prepared in high yields with good functional group tolerance. Unlike the traditional thermal tetradehydro-Diels–Alder reactions, diluted reaction concentration and radical prohibitors are not required for this protocol. Experimental data support a mechanism involving gold vinylidene species, which undergoes a 6 π electrocyclization, followed with 1,2-hydrogen shift.

An efficient approach to fused indolines via a copper(I)-catalyzed reaction of sulfonyl azide with 2-ethynylaryl methylenecyclopropane

A cascade reaction of 2-ethynylaryl methylenecyclopropane with sulfonyl azide catalyzed by copper(I) iodide under mild conditions is described, which provides a novel and efficient route for the generation of fused indolines.