1309584-72-2

Basic information

• Product Name: 1-phenethyl-3,4-epoxypiperidine
• Synonyms: 1-phenethyl-3,4-epoxypiperidine
• CAS NO: 1309584-72-2
• Molecular Weight: 203.284
• Mol File: 1309584-72-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-phenethyl-3,4-epoxypiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenethyl-3,4-epoxypiperidine(1309584-72-2)
• EPA Substance Registry System: 1-phenethyl-3,4-epoxypiperidine(1309584-72-2)

Safety Data

• Hazardous Substances Data: 1309584-72-2(Hazardous Substances Data)

Upstream product

• 103-63-9 1-phenyl-2-bromoethane 
• 6324-18-1 1-(2-phenylethyl)pyridinium bromide 
• 92039-54-8 1-(2-phenylethyl)-1,2,3,6-tetrahydropyridine 
• 110-86-1 pyridine 

Relevant articles and documents

High regiocontrol in the nucleophilic ring opening of 1-aralkyl-3,4- epoxypiperidines with amines - A short-step synthesis of 4- fluorobenzyltrozamicol and novel anilidopiperidines

Nucleophilic ring-opening reactions of three 1-aralkyl-3,4-epoxypiperidines with a series of aliphatic and aromatic amines have been investigated. Reactions in protic solvents, preferably 2-propanol, gave rise to 3-amino-piperidin-4-ols in ratios up to 20:1. Accordingly, 4- fluorobenzyltrozamicol, a highly potent ligand for the vesicular acetylcholine transporter was obtained directly from an epoxide ring opening in one step, without the need of chromatographic separation. Reactions in acetonitrile assisted by Li-salts, most suitable with LiBr, led regioselectively to trans-4-amino-piperidin-3-ols in high yields. N-Phenethyl substituted anilino-piperidinols as easily obtained by this method were converted into a series of new β-hydroxy substituted anilidopiperidines.