1309606-64-1

Basic information

• Product Name: 3-hydroxy-2-phenyl-N-p-tolylpropanamide
• Synonyms: 3-hydroxy-2-phenyl-N-p-tolylpropanamide
• CAS NO: 1309606-64-1
• Molecular Weight: 255.316
• Mol File: 1309606-64-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-2-phenyl-N-p-tolylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-2-phenyl-N-p-tolylpropanamide(1309606-64-1)
• EPA Substance Registry System: 3-hydroxy-2-phenyl-N-p-tolylpropanamide(1309606-64-1)

Safety Data

• Hazardous Substances Data: 1309606-64-1(Hazardous Substances Data)

Upstream product

• 529-64-6 Tropic acid 
• 106-49-0 p-toluidine 

Downstream Products

• 130474-03-2 N-p-tolyl-3-phenylazetidin-2-one 
• 1309606-58-3 6-methyl-3-phenyl-2,3-dihydroquinolin-4(1H)-one 

Relevant articles and documents

Synthesis of 2,3-dihydro-4(1H)-quinolones and the corresponding 4(1H)-quinolones via low-temperature fries rearrangement of N-arylazetidin-2- ones

N-Arylazetidin-2-ones of the general form 1, which are readily prepared by GoldbergBuchwald-type copper-catalyzed coupling of N-unsubstituted azetidin-2-ones with the relevant aryl halide or using Mitsunobu cyclization processes, undergo smooth Fries-rearrangement in triflic acid at 018°C to give the isomeric 2,3-dihydro-4(1H)-quinolones (2). Dehydrogenation of the latter compounds using 10% Pd on C in 1.0M aqueous sodium hydroxide/propan-2-ol mixtures at ca. 82°C provides the corresponding 4(1H)-quinolones (3).