1309656-38-9Relevant academic research and scientific papers
Non-symmetrical bis(aminoalkyl)phosphinates: New ligands with enhanced binding of Cu(ii) ions
Piasta, Karolina,Dzie?ak, Anna,Mucha, Artur,Gumienna-Kontecka, Elzbieta
, p. 7737 - 7745 (2018)
Three novel, non-symmetrical bis(aminoalkyl)phosphinic acids, L1-L3, have been synthesized and characterized. Solution studies on the coordination abilities of the ligands have shown that these compounds form various protonated mono-
A three-component Mannich-type condensation leading to phosphinic dipeptides-extended transition state analogue inhibitors of aminopeptidases
Dzie?ak, Anna,Pawe?czak, Ma?gorzata,Mucha, Artur
scheme or table, p. 3141 - 3145 (2011/06/28)
N-Protected α-aminoalkylphosphinic acids bearing a P-H function were found to be novel practical building blocks in three-component condensations with formaldehyde and secondary amines (amino acids). Such Mannich-type N-phosphonomethylation is a common approach for phosphorus acid derived substrates and leads to multifunctional (phosphonic/amino/carboxylic) compounds of diverse relevance. The utility of this reaction was examined for construction, in a single synthetic step, of advanced phosphinic pseudodipeptides designed to act as extended transition state analogue inhibitors of selected aminopeptidases. Phosphinomethylation of primary amino acids was less efficient and yielded mixtures of products which were separated into individual components, and their structures identified.
