1309664-93-4Relevant academic research and scientific papers
Mechanistic rationalization of organocatalyzed conjugate addition of linear aldehydes to nitro-olefins
Bures, Jordi,Armstrong, Alan,Blackmond, Donna G.
, p. 8822 - 8825 (2011)
Kinetic studies of the conjugate addition of propanal to nitrostyrene catalyzed by diarylprolinol ethers reveal that formation of the product iminium species is rate-determining and is promoted by both the reaction product and acid additives. The beneficial role of a dominant cyclobutane intermediate in maintaining high stereoselectivity is highlighted. This mechanistic understanding led to the design of highly productive reaction protocols.
