1309669-70-2Relevant academic research and scientific papers
Monosaccharide as a central scaffold toward the construction of salicylate-based bidentate PTP1B inhibitors via click chemistry
Tang, Yan-Hui,Hu, Min,He, Xiao-Peng,Fahnbulleh, Sando,Li, Cui,Gao, Li-Xin,Sheng, Li,Tang, Yun,Li, Jia,Chen, Guo-Rong
experimental part, p. 1000 - 1006 (2012/01/13)
The discovery of carbohydrate-based bioactive compounds has recently received considerable interest in the drug development. This paper stresses on the application of 1-methoxy-O-glucoside as the central scaffold, whereas salicylic pharmacophores were int
Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: Novel construction of PTP1B inhibitors on a sugar scaffold
Li, Cui,He, Xiao-Peng,Zhang, Yin-Jie,Li, Zhen,Gao, Li-Xin,Shi, Xiao-Xin,Xie, Juan,Li, Jia,Chen, Guo-Rong,Tang, Yun
supporting information; experimental part, p. 4212 - 4218 (2011/11/12)
With an aim of developing novel protein tyrosine phosphatase (PTP) 1B inhibitors based on sugar scaffolds, a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides was efficiently constructed via the modular and selective Cu(I)-catalyzed azide-al
