1309674-55-2Relevant academic research and scientific papers
Synthesis of 3,3-dimethylglutamic acid derivatives as DPP-IV inhibitors and evaluation of their chemical stability
Hsu, Tsu,Tsai, Ting-Yueh,Tseng, Ya-Ju,Chiou, Mei-Chun,Lu, Cheng-Tai,Chao, Yu-Sheng,Jiaang, Weir-Torn
, p. 108 - 117 (2011)
A novel five-step synthesis of Boc-3,3-dimethylglutamic acid α-ethyl ester 11 is reported. All the steps are high yielding and simple to carry out. By use of the 3,3-dimethylglutamic acid building block, we successfully discovered a novel class of DPP-IV inhibitors, Glu-Pro-Nitrile dipeptide mimics 2, with high potency (IC50 40 nM). The consequence of 3,3-dimethyl substituent on the rate of intramolecular cyclization between N-terminal amine and 5-position amide bond in different buffer solutions was also evaluated.
