13097-04-6

Basic information

• Product Name: 6-chloro-3-phenyl-1H-indazole
• Synonyms: 6-chloro-3-phenyl-1H-indazole
• CAS NO: 13097-04-6
• Molecular Weight: 228.681
• Mol File: 13097-04-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-chloro-3-phenyl-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-3-phenyl-1H-indazole(13097-04-6)
• EPA Substance Registry System: 6-chloro-3-phenyl-1H-indazole(13097-04-6)

Safety Data

• Hazardous Substances Data: 13097-04-6(Hazardous Substances Data)

Upstream product

• 503045-59-8 6-chloro-3-iodo-1H-indazole 
• 98-80-6 phenylboronic acid 

Relevant articles and documents

Copper-Promoted Oxidative Intramolecular C–H Amination of Hydrazones to Synthesize 1H-Indazoles and 1H-Pyrazoles Using a Cleavable Directing Group

A facile and efficient synthesis of 1H-indazoles and 1H-pyrazoles through a copper-promoted oxidative intramolecular C–H amination of hydrazones using a cleavable directing group was developed. This reaction is characterized by its mild conditions, operational simplicity, readily available reagents, and excellent yields. A tentative mechanism for Cu-mediated C–H oxidative amination was proposed.

ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans

The National Institutes of Health Molecular Libraries and Probe Production Centers Network (NIH-MLPCN) screened >300,000 compounds to evaluate their ability to restore fluconazole susceptibility in resistant Candida albicans isolates. Additional counter screens were incorporated to remove substances inherently toxic to either mammalian or fungal cells. A substituted indazole possessing the desired bioactivity profile was selected for further development, and initial investigation of structure-activity relationships led to the discovery of ML212.