130970-57-9Relevant articles and documents
Synthesis and in vitro activity of new cephalosporin derivatives containing a benzoxazolone ring
Kalcheva,Mincheva,Andreeva
, p. 1030 - 1034 (2007/10/02)
New cephalosporin derivatives containing a benzoxazolone ring in the side acylamino chain are synthesized using chlorides of non-substituted and halogen substituted (2-benzoxazolone-3-yl) acetic acid for the acylation of the 7-aminodesacetoxy-cephalosporanic acid and 7-aminocephalosoranic acid amino group. Some of these new compounds exhibit a biological activity higher than that of cephalexin and cephazolin against clinical strains of Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus group A and B.