130973-78-3

Basic information

• Product Name: AZETIDINE-2-CARBOXAMIDE
• Synonyms: AZETIDINE-2-CARBOXAMIDE;AZETIDINE-2-CARBOXYLIC ACID AMIDE;2-Azetidinecarboxamide;2-AzetidinecarboxaMide HCl;2-Azetidinecarboxamidehydrochloride
• CAS NO: 130973-78-3
• Molecular Formula: C4H8N2O
• Molecular Weight: 100.12
• Mol File: 130973-78-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 300.919 °C at 760 mmHg
• Flash Point: 135.791 °C
• Appearance: /
• Density: 1.172 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.504
• Storage Temp.: 2-8°C
• PKA: 16.21±0.20(Predicted)
• CAS DataBase Reference: AZETIDINE-2-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: AZETIDINE-2-CARBOXAMIDE(130973-78-3)
• EPA Substance Registry System: AZETIDINE-2-CARBOXAMIDE(130973-78-3)

Safety Data

• Hazardous Substances Data: 130973-78-3(Hazardous Substances Data)

Usage

Uses

Azetidine-2-carboxamide is used in the discovery of NVP-BYL719 I, which is a potent and selective phosphatidylinositol-3 kinase alpha inhibitor.

InChI:InChI=1/C4H8N2O/c5-4(7)3-1-2-6-3/h3,6H,1-2H2,(H2,5,7)

Upstream product

• 1219220-82-2 tert-butyl 2-carbamoylazetidine-1-carboxylate 

Downstream Products

• 103550-76-1 2-aminomethylazetidine 

Relevant articles and documents

COMPOUND INHIBITING DIPEPTIDYL PEPTIDASE IV

The invention aims to provide a dipeptidyl peptidase IV inhibitor which is satisfactory in respect of activity, stability and safety and has an excellent action as a pharmaceutical agent. The invention is directed to a compound represented by the following general formula or a pharmaceutically acceptable salt thereof: wherein R1 and R2 each represents hydrogen, an optionally substituted C1-6 alkyl group, or -COOR5 whereupon R5 represents hydrogen or an optionally substituted C1-6 alkyl group, or R1 and R2, together with a carbon atom to which they are bound, represent a 3- to 6-membered cycloalkyl group, R3 represents hydrogen or an optionally substituted C6-10 aryl group, R4 represents a hydrogen or a cyano group, D represents -CONR6-, -CO- or -NR6CO-, R6 represents hydrogen or an optionally substituted C1-6 alkyl group, E represents -(CH2)m- whereupon m is an integer of 1 to 3, -CH2OCH2-, or -SCH2-, n is an integer of 0 to 3, and A represents an optionally substituted bicyclic heterocyclic group or bicyclic hydrocarbon group.