1309761-40-7Relevant academic research and scientific papers
A simple and efficient copper-catalyzed synthesis of N-alkynylimidazoles
Wang, Man-Gang,Wu, Jun,Shang, Zhi-Cai
supporting information; experimental part, p. 589 - 594 (2012/03/27)
A simple and efficient method for the synthesis of N-alkynylheteroarenes from 1,1-dibromo-1-alkenes was developed via a copper-catalyzed cross-coupling reaction. Generally superior yields and functional-group tolerance were obtained with TMEDA as ligand using imidazole and benzimidazole substrates in dioxane. Georg Thieme Verlag Stuttgart · New York.
Copper-mediated selective cross-coupling of 1,1-dibromo-1-alkenes and heteronucleophiles: Development of general routes to heterosubstituted alkynes and alkenes
Jouvin, Kevin,Coste, Alexis,Bayle, Alexandre,Legrand, Frederic,Karthikeyan, Ganesan,Tadiparthi, Krishnaji,Evano, Gwilherm
, p. 7933 - 7947 (2013/01/16)
Efficient and general procedures for the cross-coupling of 1,1-dibromoalkenes and N-, O-, and P-nucleophiles are reported. Fine-tuning of the reaction conditions allows for either site-selective, double, or alkynylative cross-coupling, therefore providing
Copper-catalyzed coupling of imidazoles and pyrazoles with 1,1-dibromo-1-alkenes: A distinct approach for direct N-alkynylation of heteroarenes
Das, Biswanath,Salvanna,Reddy, Gandolla Chinna,Balasubramanyam, Penagaluri
experimental part, p. 6497 - 6500 (2011/12/15)
The direct N-alkynylation of heteroarenes, imidazoles, and pyrazoles with 1,1-dibromo-1-alkene has been carried out for the first time using [Cu(Phen)PPh3Br] (as a catalyst) and Cs2CO3 in DMSO at 80 °C. The products are formed in good to high yields (66-85%) within 3 h. No side products could be detected.
