1309766-89-9

Upstream product

• 1309766-85-5 allyl (3S,4R,5S)-4-[(S)-2-{(R)-2-[(E)-(S)-3-hydroxy-7-(tritylthio)-4-heptenoylamino]propionylamino}-3-(tritylthio)propionylamino]-3-hydroxy-5-methylheptanoate 
• 3695-77-0 triphenylmethanethiol 
• 133645-50-8 (3S,4R,5S)-4-((tert-butoxycarbonyl)amino)-3-hydroxy-5-methylheptanoic acid 
• 150350-28-0 S-trityl 3-mercaptopropionaldehyde 
• 180973-22-2 (2E)-5-[(triphenylmethyl)thio]-2-pentenal 
• 180973-24-4 (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid 
• 1309766-88-8 allyl (3S,4R,5S)-4-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]-3-(tritylthio)propionylamino}-3-hydroxy-5-methylheptanoate 
• 1309766-87-7 (3S,4R,5S)-allyl 4-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(tritylthio)propanamido)-3-hydroxy-5-methylheptanoate 
• 1309766-93-5 (3S,4R,5S)-allyl 4-(tert-butoxycarbonylamino)-3-hydroxy-5-methylheptanoate 
• 878630-47-8 (E)-(S)-3-hydroxy-1-[(R)-4-isopropyl-5,5-diphenyl-2-oxo-oxazolidin-3-yl]-7-tritylthio-4-hepten-1-one 

Relevant academic research and scientific papers

Total synthesis of spiruchostatin B aided by an automated synthesizer

The total synthesis of a natural product HDAC inhibitor, spiruchostatin B, was successfully achieved. A 5-step synthesis that included an asymmetric aldol reaction was carried out in an automated synthesizer to provide an (E)-(S)-3-hydroxy-7-thio-4-heptenoic acid segment that is the crucial structure of cysteine-containing, depsipeptidic natural products such as spiruchostatins, FK228, FR901375, and largazole for their inhibitory activity against HDACs.