130980-00-6

Basic information

• Product Name: Ethanone, 2,2,2-trifluoro-1-(2-phenylcyclopropyl)-, (1R-trans)- (9CI)
• Synonyms: Ethanone, 2,2,2-trifluoro-1-(2-phenylcyclopropyl)-, (1R-trans)- (9CI)
• CAS NO: 130980-00-6
• Molecular Formula: C₁₁H₉F₃O
• Molecular Weight: 214.1837696
• Product Categories: ACETYLHALIDE
• Mol File: 130980-00-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 2,2,2-trifluoro-1-(2-phenylcyclopropyl)-, (1R-trans)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2,2,2-trifluoro-1-(2-phenylcyclopropyl)-, (1R-trans)- (9CI)(130980-00-6)
• EPA Substance Registry System: Ethanone, 2,2,2-trifluoro-1-(2-phenylcyclopropyl)-, (1R-trans)- (9CI)(130980-00-6)

Safety Data

• Hazardous Substances Data: 130980-00-6(Hazardous Substances Data)

Upstream product

• 108644-86-6 (Z)-(R)-1-phenyl-3-hydroxy-4,4,4-trifluoro-1-butene 
• 128726-28-3 (R)-2,2,2-Trifluoro-1-((1R,2S)-2-phenyl-cyclopropyl)-ethanol 
• 108644-85-5 (E)-(R)-1,1,1-trifluoro-4-phenyl-3-buten-2-ol 
• 130980-04-0 (R)-2,2,2-Trifluoro-1-((1R,2R)-2-phenyl-cyclopropyl)-ethanol 

Downstream Products

• 130980-03-9 (S)-2,2,2-Trifluoro-1-((1S,2S)-2-phenyl-cyclopropyl)-ethanol 
• 130980-05-1 (S)-2,2,2-Trifluoro-1-((1S,2R)-2-phenyl-cyclopropyl)-ethanol 

Relevant articles and documents

Organocatalytic Aerobic Oxidation of α-Fluoroalkyl Alcohols to Fluoroalkyl Ketones at Room Temperature

The organocatalytic aerobic oxidation of electron-deficient α-fluoroalkyl alcohols at room temperature is described. The resulting fluoroalkyl ketones are versatile synthetic intermediates for a variety of fluorine-containing molecules. This otherwise difficult transformation has now been accomplished by the reaction of α-fluoroalkyl alcohols with N-oxyl radicals, catalytically generated from 9-azabicyclo[3.3.1]nonan-3-one N-oxyl/nitrogen oxide (keto-ABNO/NOx) and oxygen in acetic acid (AcOH), affording the corresponding fluoroalkyl ketones in high yield. This operationally simple reaction can be performed under mild conditions, and was applied to a wide range of alcohols (20 examples), thus demonstrating a high functional group tolerance. Moreover, a modified one-pot protocol based on this method was able to convert an aldehyde to a trifluoromethyl ketone on a gram scale.