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Upstream product

• 121-33-5 vanillin 
• 108-46-3 recorcinol 

Relevant academic research and scientific papers

Synthesis of C-4-hydroxy-3-methoxyphenylcalix[4]resorcinarene and its application as adsorbent for lead(II), copper(II) and chromium(III)

This study aims to synthesize C-4-hydroxy-3-methoxyphenylcalix[ 4]resorcinarene and investigate the kinetics of its application as an adsorbent for lead(II), copper(II) and chromium( III) ions. The interaction between this adsorbent and these metal ions was also studied. In this work, C-4-hydroxy- 3-methoxyphenylcalix[4]resocinarene was synthesized from vanillin and resorcinol as a light red solid in 84% yield, and its ability to adsorb the metal ions was conducted in a batch system. The kinetics and interaction of the adsorbent with these metal ions were analyzed by FAAS spectrometry and FT-IR respectively. The optimum pH values of this adsorbent to adsorb Pb(II), Cu(II) and Cr(III) ions were determined to be 5.48, 5.70 and 4.50 respectively. The adsorption rate order of these metal ions onto adsorbent was found to be Pb(II) > Cu(II) > Cr(III). The competitive adsorption of these heavy metal ions was also investigated. FT-IR spectra showed the presence of interaction between Pb(II) and the adsorbent, but no such interaction was observed between the adsorbent and Cr(III) or Cu(II). Further studies based on the 1HNMR and UV spectra of the free and metal ion loaded adsorbents confirmed the presence of interaction between the adsorbent and all metal cations.

Comparative study on the antioxidant and anti-Toxoplasma activities of vanillin and its resorcinarene derivative

A resorcinarene derivative of vanillin, resvan, was synthesized and characterized by spectroscopic techniques. We measured the cytotoxicity (in vivo and in vitro), antioxidant and anti-Toxoplasma activities of vanillin and the resorcinarene compound. Here we show that vanillin has a dose-dependent behavior with IC50 of 645 μg/mL through an in vitro cytotoxicity assay. However, we could not observe any cytotoxic response at higher concentrations of resvan (IC50 > 2,000 μg/mL). The in vivo acute toxicity assays of vanillin and resvan exhibited a significant safety margin indicated by a lack of systemic and behavioral toxicity up to 300 mg/kg during the first 30 min, 24 h or 14 days after administration. The obtained derivative showed greater antioxidative activity (84.9%) when comparing to vanillin (19.4%) at 1,000 μg/mL. In addition, vanillin presents anti-Toxoplasma activity, while resvan does not show that feature. Our findings suggest that this particular derivative has an efficient antioxidant activity and a negligible cytotoxic effect, making it a potential target for further biological investigations.