130982-23-9

Upstream product

• 1685-84-3 7-methoxy-6-methyl-1-tetralone 
• 1256358-40-3 2-(triphenylphosphoranylidene)propanethioic acid S-(2,6-dimethylphenyl) ester 
• 130921-11-8 (±)-2-hydroxy-6-methoxy-4,7-dimethyl-3,4-dihydronaphthalen-1(2H)-one 
• 1397694-71-1 C₁₆H₂₀O₅ 
• 1397694-70-0 5-(2,3-dihydroxypropyl)-4-(4-methoxy-3-methylphenyl)-3-methylfuran-2(5H)-one 
• 1397694-72-2 5-allyl-4-(4-methoxy-3-methylphenyl)-3-methylfuran-2(5H)-one 
• 1397694-64-2 7-methoxy-1,8-dimethyl-3a,4-dihydronaphtho[2,1-b]furan-2,5-dione 
• 1397694-65-3 2-(3-(4-methoxy-3-methylphenyl)-4-methyl-5-oxo-2,5-dihydrofuran-2-yl)acetic acid 
• 130921-13-0 trans-2-Dimethylphosphonoacetyloxy-6-methoxy-4,7-dimethyltetral-1-one 
• 130921-13-0 cis-2-Dimethylphosphonoacetoxy-6-methoxy-4,7-dimethyltetral-1-one 
• 130921-11-8 trans-2-Hydroxy-6-methoxy-4,7-dimethyltetral-1-one 
• 130921-09-4 4-(3-methoxy-4-methyl-phenyl)-valeric acid 
• 143837-18-7 2-<(3,8-Dimethyl-2-methoxy-7,8-dihydro)-5-naphthyl>propionic acid ethylester 
• 130921-10-7 (±)-methoxy-4,7-dimethyl-3,4-dihydronaphthalen-1(2H)-one 

Relevant academic research and scientific papers

A new approach to (±)-heritonin. The preparation of β-tetralones from allylsilanes and acid chlorides

A new method for the preparation of 4-alkyl-β-tetralones is described, by reaction of arylacetic acid chlorides with allylsilanes. Employing β-tetralone 5, the synthesis of (±)-heritonine and (±)-epi-heritonine, natural piscicides isolated from Heritiera littoralis, was achieved in four steps and 22% overall yield. The key step of this synthesis involved the selenocarbenium ion-mediated elaboration of the butenolide ring of the natural product.

A highly diastereoselective total synthesis of (±)-heritonin and (±)-heritol

A highly diastereoselective synthesis of heritol and heritonin by intramolecular cyclization on a preformed sensitive butenolide functionality is described. Graphical abstract:

Cu(II)-catalyzed acylation by thiol esters under neutral conditions: Tandem acylation-wittig reaction leading to a one-pot synthesis of butenolides

The first catalytic acylation of alcohols with a thiol ester present in Wittig reagents under neutral conditions catalyzed by the Cu(II) salt through a push-pull mechanism is reported. Furthermore, a new methodology for the one-pot lactonization of acyloins by a copper catalyst is developed. The synthetic utility of this method for the synthesis of natural products is shown.

SYNTHESIS OF (+/-)-HERITOL

Synthesis of (+/-)-heritol and epi-heritol is described.The key step is the osmylation of the unsaturated ester 9a.Osmylation is used as a tool to construct the α,β-unsaturated γ-lactone system.