130984-55-3Relevant academic research and scientific papers
Addition reactions of chloro- Or iodomethyllithium to imines. Synthesis of enantiopure aziridines and β-chloroamines
Concellon, Jose M.,Rodriguez-Solla, Humberto,Bernad, Pablo L.,Simal, Carmen
experimental part, p. 2452 - 2459 (2009/07/18)
We report a novel, simple, and efficient synthesis of aziridines and l-chloroalkan-2-amines by the reaction of imines derived from various aldehydes and p-toluenesulfonamide or benzenesulfonamide with iodoor chloromethyllithium, respectively. Both halogenated anions were generated in situ by treatment of diiodo- or chloroiodomethane with methyllithium at -78 or 0 °C. The reaction of in situ generated iodoor chloromethyllithium could also be performed from chiral 2-aminoaldimines to yield enantiopure aziridines or (2S,3S)-2,3-diamino- l-chloroalkanes with high stereoselectivity.
Stereoselective synthesis of α,β-diamino nitriles from amino acids
Reetz,Hubel,Jaeger,Schwickardi,Goddard
, p. 733 - 738 (2007/10/02)
α-Amino acids 1 are readily converted into the corresponding N,N-dibenzylamino aldehydes 2 which in turn serve as starting materials for enantiomerically pure α-N,N-dibenzylamino aldimines 5, 6 and 7 having benzyl, tosyl and trimethylsilyl groups, respect
