130985-16-9Relevant articles and documents
1-(Arylmethyl)quinazoline-2,4(1H,3H)-diones as PARP Inhibitors and the Use Thereof
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Paragraph 0586, (2014/02/16)
Disclosed are 1-(arylmethyl)quinazoline-2,4(1H,3H)-diones thereof, represented by the Formula (I) wherein Ar, R1-R6 are defined herein. Compounds having Formula (I) are PARP inhibitors. Therefore, compounds of the invention may be us
Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase
Lowe III,Archer,Chapin,Cheng,Helweg,Johnson,Koe,Lebel,Moore,Nielsen,Russo,Shirley
, p. 624 - 628 (2007/10/02)
A series of quinazolinediones and azaquinazolinediones is described which possess potent inhibitory activity toward the calcium-independent phosphodiesterase enzyme (CaIPDE). In vivo testing showed that this in vitro activity translates to animal models p