1309926-69-9Relevant academic research and scientific papers
Synthesis, spectroscopic, thermal and biological aspects of drug-based copper(II) complexes
Patel, Paresh N.,Patel, Darshana J.,Patel, Hasmukh S.
, p. 454 - 463 (2011)
A series of novel complexes of the type Cu(II)(Ln) 2(H2O)2]?xH2O [where Ln = L1-4, these ligands being described as: L 1, 2-({4-[6,7-dihydrothieno[3,2-c]pyridin-5(4H)-ylsulfonyl] phenylimino}methyl)phenol, x = 1; L2, 2-({4-[6,7-dihydrothieno[3,2-c] pyridin-5(4H)-ylsulfonyl]phenylimino}methyl)-5-(methoxy)phenol, x = 2; L 3, 5-chloro-2-({4-[6,7-dihydrothieno[3,2-c]pyridin-5(4H)-ylsulfonyl] phenylimino}methyl)phenol, x = 2; and L4, 5-bromo-4-chloro-2-({4-[6, 7-dihydrothieno[3,2-c]pyridin-5(4H)-ylsulfonyl]phenylimino} methyl)phenol, x = 1] was investigated. They were characterized by elemental analysis, IR, 1H-NMR, 13C-NMR and electronic spectra, magnetic measurements and thermal studies. The FAB-mass spectrum of [Cu(II)(L 1)2(H2O)2]?H 2O was determined. A magnetic moment and reflectance spectral study revealed that an octahedral geometry could be assigned to all the prepared complexes. Ligands (Ln) and their metal complexes were screened for their in vitro antibacterial activity against Bacillus subtillis, Pseudomonas aeruginosa, Escherichia coli and Serratia marcescens bacterial strains. Kinetic parameters such as order of reaction (n), the energy of activation (E a), the pre-exponential factor (A), the activation entropy (ΔS≠), the activation enthalpy (ΔH≠) and the free energy of activation (ΔG≠) are reported.
