1309936-23-9Relevant academic research and scientific papers
Solvent- and ligand-induced switch of selectivity in gold(I)-catalyzed tandem reactions of 3-propargylindoles
Alvarez, Estela,Miguel, Delia,Garcia-Garcia, Patricia,Fernandez-Rodriguez, Manuel A.,Rodriguez, Felix,Sanz, Roberto
supporting information; experimental part, p. 786 - 793 (2011/07/30)
The selectivity of our previously described gold-catalyzed tandem reaction, 1,2-indole migration followed by aura-iso-Nazarov cyclization, of 3-propargylindoles bearing (hetero)aromatic substituents at both the propargylic and terminal positions, was reversed by the proper choice of the catalyst and the reaction conditions. Thus, 3-(inden-2-yl)indoles, derived from an aura-Nazarov cyclization (instead of an aura-iso-Nazarov cyclization), were obtained in moderate to good yields from a variety of 3-propargylindoles.
