130995-65-2

Basic information

• Product Name: N-tert-butyl-α-(2-methoxy)phenylnitrone
• Synonyms: N-tert-butyl-α-(2-methoxy)phenylnitrone
• CAS NO: 130995-65-2
• Molecular Weight: 207.272
• Mol File: 130995-65-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-tert-butyl-α-(2-methoxy)phenylnitrone(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-butyl-α-(2-methoxy)phenylnitrone(130995-65-2)
• EPA Substance Registry System: N-tert-butyl-α-(2-methoxy)phenylnitrone(130995-65-2)

Safety Data

• Hazardous Substances Data: 130995-65-2(Hazardous Substances Data)

Upstream product

• 594-70-7 2-Methyl-2-nitropropane 
• 135-02-4 ortho-anisaldehyde 
• 128072-71-9 2-tert-Butyl-3-(2-methoxy-phenyl)-oxaziridine 
• 82632-38-0 N-tert-butyl-1-(2-methoxyphenyl)methanimine 

Downstream Products

• 1383738-69-9 (S)-2-tert-butyl-3-(2-methoxyphenyl)-5-phenyl-2,3-dihydroisoxazole-4-carbaldehyde 

Relevant articles and documents

Reactivities of MeO-substituted PBN-type nitrones

In this work, α-phenyl-N-tert-butylnitrone (PBN), N-benzylidene-1-diethoxyphosphoryl-1-methylethylamine N-oxide (PPN) and N-benzylidene-1-ethoxycarbonyl-1-methylethylamine N-oxide (EPPN) derivatives bearing methoxy groups (MeO-) on the phenyl ring were sy

Nitrone derivatives

A compound represented by the figure (1) or a pharmaceutically acceptable salt thereof is useful as medicament for treating retinal degenerative disorders: wherein Ar is optionally substitued phenyl or optionally substituted heteroaryl;. n is 0, 1 or 2; W

Rearrangement Reactions of Oxaziridines to Nitrones. X-Ray Crystal and Molecular Structure of N-t-Butyl-α(o-hydroxyphenyl)nitrone

Substituted N-benzylidene-t-butylamines are oxidized with m-chloroperoxybenzoic acid to oxaziridines which can rearrange to the corresponding nitrones when electron-donating groups are present in the phenyl ring.The oxaziridine-to-nitrone rearrangement, which has been considered as a 'pseudo-abnormal' reaction, can also be catalysed by Lewis acids.It has been found that the rearrangement of 2-t-butyl-3-(o-hydroxyphenyl)oxaziridine to the corresponding nitrone is of first order.The rearrangement has been investigated for different substituents in the phenyl ring, andin the case of 2-t-butyl-3-phenyloxaziridine substituted in the ortho position with electron-donating groups it has been found that the presence of protons of a Lewis acid is necessary.An X-ray structure of α-(o-hydroxyphenyl)-N-t-butylnitrone shows strong hydrogen bonding between the nitrone oxygen and the hydrogen in the hydroxy group.The oxaziridine-to-nitrone rearrangement is also analysed from a theoretical point of view using ab initio calculations.A Mulliken-population analysis of the C-O and N-O bonds in the oxaziridine ring for para-substitued 2-t-butyl-3-phenyloxaziridines shows a reduction of the C-O bond population when an electron-donating group is present in the para position of the phenyl ring compared with an electron-withdrawing group; the N-O bond populations show the reverse picture.A state-correlation diagram for the oxaziridine-to-nitrone rearrangement is also presented and the experimental and theoretical results support each other.