1309955-89-2Relevant academic research and scientific papers
Enantioselective synthesis of the ABC ring motif of norzoanthamine based on asymmetric robinson annulation reactions
Nguyen, Thong X.,Dakanali, Marianna,Trzoss, Lynnie,Theodorakis, Emmanuel A.
, p. 3308 - 3311 (2011/09/15)
An enantioselective strategy for the synthesis of tetracyclic motif 5, representing the northern fragment of norzoanthamine, is presented. Key to the strategy is the use of two asymmetric Robinson annulation reactions that produce the tricyclic ABC ring system with excellent stereoselectivity. Further functionalization at the periphery of the C ring produces compound 5 containing six contiguous stereocenters of the natural product.
