130996-24-6

Basic information

• Product Name: Dehydro Lacidipine
• Synonyms: (E)-4-[2-[3-(1,1-Dimethylethoxy)-3-oxo-1-prphenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Diethyl Ester;Dehydro Lacidipine;GR 510922qopenyl];GR 51092X;(E)-4-[2-[3-(1,1-Dimethylethoxy)-3-oxo-1-propenyl]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester;GR 51092;Lacidipine BP Impurity B;Lacidipine EP Impurity B
• CAS NO: 130996-24-6
• Molecular Formula: C₂₆H₃₁NO₆
• Molecular Weight: 453.52744
• Product Categories: Heterocyles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Heterocyles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 130996-24-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 75-78?C
• Boiling Point: 545.9°C at 760 mmHg
• Flash Point: 284°C
• Appearance: /
• Density: 1.134g/cm³
• Vapor Pressure: 5.64E-12mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: Dehydro Lacidipine(CAS DataBase Reference)
• NIST Chemistry Reference: Dehydro Lacidipine(130996-24-6)
• EPA Substance Registry System: Dehydro Lacidipine(130996-24-6)

Safety Data

• Hazardous Substances Data: 130996-24-6(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

The main metabolite of Lacidipine.

InChI:InChI=1/C26H31NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15H,8-9H2,1-7H3/b15-14+

Upstream product

• 103890-78-4 Lacidipine 

Relevant articles and documents

Preparation method of lacidipine impurity B

The invention relates to the technical field of pharmacy, and particularly discloses a preparation method of a lacidipine impurity B. The preparation method comprises the following steps: step 1), adding lacidipine into a solvent, and stirring until lacidipine is dissolved to obtain a prepared solution; step 2) slowly adding DDQ into the prepared solution at the speed of 1.0-3.0 g/min, stirring for more than 10 minutes at the stirring speed of 250-350 rpm at the temperature of 0-50 DEG C, and then filtering to obtain an organic phase, namely a lacidipine impurity B solution, wherein the molarratio of lacidipine to DDQ is 1: 1-3; and step 3) washing the lacidipine impurity B solution with a weak base aqueous solution, washing with a saturated sodium chloride aqueous solution, and spin-drying to obtain the yellow solid lacidipine impurity B. The method has the characteristics of short reaction time, simple preparation process and suitability for industrial production, and the prepared lacidipine impurity B has the advantages of high purity and good properties.