1309972-83-5Relevant academic research and scientific papers
Environmentally benign syntheses of flavanones
Chen, Po-Yuan,Wang, Tzu-Pin,Chiang, Michael Y.,Huang, Keng-Shian,Tzeng, Cherng-Chyi,Chen, Yi-Long,Wang, Eng-Chi
, p. 4155 - 4160 (2011)
Mild and environmentally benign methods for the syntheses of flavanones are described. The reaction of o-hydroxyacetophenones (1) and benzaldehydes (2) in water in the presence of DABCO at room temperature gave 3-hydroxy-1-(2- hydroxylphenyl)-3-arylpropan-1-ones (3a-i) as intermediates. Followed by an intramolecular dehydration of the 3a-i with the modified Mitsunobu's reaction, the target flavanones (4a-i) were obtained. Moreover, the reaction of 1 and 2 at the same conditions but at reflux gave flavanones in one pot with good yields.
