131-52-2 Usage
Description
Pentachlorophenol (PCP) can be found in two forms: pentachlorophenol
itself or as the sodium salt of pentachlorophenol
(NaPCP). These two forms have some different physical
properties, but are expected to have similar toxic effects. PCP is
a synthetic substance, made from other chemicals, and does
not occur naturally in the environment. Although PCP was first
synthesized in 1841, it was not produced commercially until
1936. It has since been registered for use as an insecticide,
fungicide, herbicide, algicide, and disinfectant. By 1967, PCP
and its sodium salt, NaPCP, were used extensively in industry
and agriculture, due in large part to the solubility of PCP in
organic solvents and of NaPCP in water. In 1977, both were
listed together as the second most heavily used pesticide in the
United States.
Chemical Properties
Different sources of media describe the Chemical Properties of 131-52-2 differently. You can refer to the following data:
1. Sodium pentachlorophenate is a crystalline solid. Phenolic odor.
2. White or tan powder. Soluble in water,
ethanol, and acetone; insoluble in benzene.
Uses
Different sources of media describe the Uses of 131-52-2 differently. You can refer to the following data:
1. Fungicide; herbicide; slimicide; fermentation
disinfectant, especially in finishes and papers.
2. PCP and its water soluble salt, NaPCP, are commercially
produced organochlorine compounds used primarily as the
preservatives of wood and wood products, and secondarily
as herbicides, insecticides, fungicides, molluscicides, and
bactericides.
General Description
Sodium pentachlorophenolate is a white or tan, powdered solid. Sodium pentachlorophenolate is soluble in water and may burn, but Sodium pentachlorophenolate is not easily ignited. Sodium pentachlorophenolate may be toxic by ingestion, inhalation and skin absorption. Sodium pentachlorophenolate is used as a fungicide, herbicide and as a disinfectant.
Air & Water Reactions
Soluble in water.
Reactivity Profile
Sodium pentachlorophenolate is incompatible with strong oxidizing agents.
Hazard
Toxic by ingestion, inhalation; skin irritant.
Health Hazard
Exposure can cause irritation of eyes, nose and throat. May cause weakness, excessive sweating, headache, dizziness, nausea, vomiting, and difficulty in breathing.
Fire Hazard
Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as hydrogen chloride, polychlorodibenzodioxins and carbon monoxide, may be formed when involved in fire.
Safety Profile
Poison by ingestion, inhalation, skin contact, intravenous, intraperitoneal, subcutaneous, and intratracheal routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Cland Na2O. See also CHLOROPHENOLS.
Potential Exposure
Uses include: wood preservative; as a fungicide in water-based latex paints; preservation of cellulose products, textiles, adhesives, leather, pulp, paper, and industrial waste systems; a contact and preemergence herbicide; general disinfectant and control of the intermediate snail host of schistosomiasis. The technical grade of sodium pentachlorophenate usually contain toxic microcontaminants including polychlorinated dibenzodioxins and dibenzofurans (132-64-9, and others).
Carcinogenicity
Data from a wide range and
large number of studies evaluating the carcinogenic potential
of pentachlorophenol are available. These include three longterm
carcinogenicity studies in mice, three in
rats, two studies evaluating the potential
of pentachlorophenol to act as promoter in the carcinogenic
process, and a “stop exposure” study. The
results of the initiation and/or promotion studies are uniformly
negative, as are the results of all the rat studies and two
of the three long-term mouse studies. In addition, a very large
body of genotoxicity evidence suggests that pentachlorophenol
is nonmutagenic.
Environmental Fate
Routes and pathways, relevant physicochemical properties
Solubility: in water 330 g l-1 at 25 °C; soluble in ethanol,
acetone; insoluble in benzene and petroleum oils.
Partition behavior in water, sediment, and soil
If released to air, NaPCP will exist solely in the aerosol
phase in the ambient atmosphere. The aerosol phase will be
removed from the atmosphere by wet and dry deposition. If released to soil and water under typical ambient conditions
(pH 5–9), NaPCP is expected to exist predominately in
its dissociated form (pKa 4.7). Releases to soil can decrease
in concentration due to slow biodegradation (half-life is
weeks to months) and leaching into groundwater. Releases
to water may photolyze (half-life is hours to days with
rate decreasing with depth of water), biodegrade, adsorb
to sediments, or bioaccumulate in aquatic organisms.
Biodegradation probably becomes significant after a period
of acclimation.Environmental persistencyNaPCP is not persistent in water, sewage, or soil because of
bacterial decomposition. PCP readily decomposes in sunlight
to monomeric and dimeric oxidation products in water.
Principal decompose products are tetrachlororesorcinol,
chloranilic acid, and dimeric products.Bioaccumulation and biomagnificationSodium pentachlorophenol did not appear to bioaccumulate
in aquatic organisms to very high concentrations.
BCFs for the compound were <1000 for most species
tested.
Shipping
UN2567 Sodium pentachlorophenate, Hazard Class: 6.1; Labels: 6.1-Poisonous materials
Toxicity evaluation
The biochemical action of pentachlorophenol is active
uncoupling of oxidation phosphorylation. PCP binds to
mitochondrial protein and inhibits mitochondrial ATP-ase
activity. Thus, both the formation of ATP and the release of
energy to the cell from the breakdown of ATP to ADP are
prevented. Electron transport is not inhibited by PCP, although
reactions dependent on available high-energy bonds, such as
oxidative and glycolytic phosphorylation, are affected. Binding
to enzymatic protein has been reported and may lead to the
inhibition of other cellular enzymes. There is also an increase in
cellular oxygen demand during the uncoupling of oxidative
phosphorylation. This causes the initial rise in respiration rate
reported in individuals poisoned by PCP.
Incompatibilities
Uses include: wood preservative; as a fungicide in water-based latex paints; preservation of cellulose products, textiles, adhesives, leather, pulp, paper, and industrial waste systems; a contact and preemergence herbicide; general disinfectant and control of the intermediate snail host of schistosomiasis. The technical grade of sodium pentachlorophenate usually contain toxic microcontaminants including polychlorinated dibenzodioxins and dibenzofurans (132-64-9, and others).
Waste Disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal.
Check Digit Verification of cas no
The CAS Registry Mumber 131-52-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 1 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 131-52:
(5*1)+(4*3)+(3*1)+(2*5)+(1*2)=32
32 % 10 = 2
So 131-52-2 is a valid CAS Registry Number.
InChI:InChI=1/C6HCl5O.Na/c7-1-2(8)4(10)6(12)5(11)3(1)9;/h12H;/q;+1
131-52-2Relevant articles and documents
Sodium pentachlorophenol liquid product preparation method
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Paragraph 0018-0020, (2017/01/12)
The present invention discloses a sodium pentachlorophenol liquid product preparation method, which comprises that phenol and chlorine gas are subjected to a chlorine hydrogen substitution reaction to generate a pentachlorophenol melting liquid; the pentachlorophenol melting liquid is subjected to water breaking to form multi-gap sand-like pentachlorophenol solid; the pentachlorophenol solid and a sodium hydroxide solution are subjected to a neutralization reaction to generate a sodium pentachlorophenol crude solution; and the sodium pentachlorophenol crude solution is subjected to concentration regulation with water, and filling is performed to form the sodium pentachlorophenol liquid product. According to the present invention, the three processes such as evaporation, crystallization and centrifugation dehydration are eliminated, the electricity consumption, the natural gas consumption and the water consumption are saved, no irritating gas overflows during the operation process, the process is safe and controllable, the automation can be completely achieved, the production efficiency is significantly improved, and the production cost is significantly reduced.
