1310048-52-2Relevant academic research and scientific papers
Redox-based probes for protein tyrosine phosphatases
Leonard, Stephen E.,Garcia, Francisco J.,Goodsell, David S.,Carroll, Kate S.
, p. 4423 - 4427 (2011/06/26)
Three in one: The design strategy for redox-based probes (RBPs) that detect the reversible oxidation of protein tyrosine phosphatases (PTPs) includes a "warhead" that forms a covalent adduct with the oxidized active site cysteine of PTPs, a synthetic module that directs binding to the PTP active site, and a chemical reporter tag used for the identification, purification, or direct visualization of the probe-labeled proteins (see picture). Copyright
