1310057-27-2Relevant academic research and scientific papers
Single enantiomer synthesis of α-(trifluoromethyl)-β-lactam
Jurcik, Vaclav,Slawin, Alexandra M.Z.,O'Hagan, David
experimental part, p. 759 - 766 (2011/07/31)
The first synthesis of α-(trifluoromethyl)-β-lactam ((S)-1) is reported. The route starts from α-(trifluoromethyl)acrylic acid (2). Conjugate addition of α-(p-methoxyphenyl)ethylamine ((S)-3b), generated an addition adduct 4b which was cyclised to β-lacta
