1310065-55-4Relevant academic research and scientific papers
Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells
Suhara, Yoshitomo,Hirota, Yoshihisa,Hanada, Norika,Nishina, Shun,Eguchi, Sachiko,Sakane, Rie,Nakagawa, Kimie,Wada, Akimori,Takahashi, Kazuhiko,Tokiwa, Hiroaki,Okano, Toshio
, p. 7088 - 7092 (2015)
We synthesized new vitamin K2 analogues with ω-terminal modifications of the side chain and evaluated their selective differentiation of neuronal progenitor cells into neurons in vitro. The result of the assay showed that the menaquinone-3 analogue modified with the m-methylphenyl group had the most potent activity, which was twice as great as the control. This finding indicated that it is possible to obtain much more potent compounds with modification of the structure of vitamin K2.
Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs
Temple, Kayla J.,Wright, Elia N.,Fierke, Carol A.,Gibbs, Richard A.
, p. 3499 - 3502 (2016)
Protein geranylgeranylation is a type of post-translational modification that aids in the localization of proteins to the plasma member where they elicit cellular signals. To better understand the isoprenoid requirements of GGTase-I, a series of aryl-modi
Synthesis of novel vitamin K2 analogues with modification at the Ω-terminal position and their biological evaluation as potent steroid and xenobiotic receptor (SXR) agonists
Suhara, Yoshitomo,Watanabe, Masato,Nakagawa, Kimie,Wada, Akimori,Ito, Yoichi,Takeda, Kazuyoshi,Takahashi, Kazuhiko,Okano, Toshio
supporting information; experimental part, p. 4269 - 4273 (2011/08/22)
Vitamin K2 is a ligand for a nuclear receptor, steroid and xenobiotic receptor (SXR), that induces the gene expressions of CYP3A4. We synthesized vitamin K2 analogues with hydroxyl or phenyl groups at the Ω-terminal of the side chain. The up-regulation of SXR-mediated transcription of the target gene by the analogues was dependent on the length of the side chain and the hydrophobicity of the Ω-terminal residues. Phenyl analogue menaquinone-3 was as active as the known SXR ligand rifampicin.
