1310072-01-5Relevant academic research and scientific papers
Synthesis of new 2-substituted 3-amino-4-hydroxymethylthiophenes through intramolecular nitrile oxide cycloaddition processes and N,O-bond cleavage
Pistara, Venerando,Corsaro, Antonino,Chiacchio, Maria A.,Greco, Graziella,Quadrellib, Paolo
experimental part, p. 270 - 285 (2011/09/20)
A synthesis of new 2-substituted 3-amino-4-hydroxymethylthiophenes 7 is reported as a useful alternative to the long known oximation of oxothiophenes 8, followed by treatment with gaseous hydrochloric acid in a polar solvent. The synthesis consists of an
