1310106-31-0

Basic information

• Product Name: 2-methoxyethyl 4-(6-bromo-4-oxo-4H-chromen-3-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS NO: 1310106-31-0
• Molecular Weight: 437.247
• Mol File: 1310106-31-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-methoxyethyl 4-(6-bromo-4-oxo-4H-chromen-3-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxyethyl 4-(6-bromo-4-oxo-4H-chromen-3-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate(1310106-31-0)
• EPA Substance Registry System: 2-methoxyethyl 4-(6-bromo-4-oxo-4H-chromen-3-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate(1310106-31-0)

Safety Data

• Hazardous Substances Data: 1310106-31-0(Hazardous Substances Data)

Upstream product

• 1450-75-5 5-Bromo-2-hydroxyacetophenone 
• 1927-95-3 4-bromophenyl acetate 
• 106-41-2 4-bromo-phenol 
• 52817-12-6 6-bromo-4-oxo-4H-chromene-3-carbaldehyde 
• 22502-03-0 2-methoxyethyl-3-oxobutanoate 
• 57-13-6 urea 

Relevant articles and documents

Synthesis, structure-activity relationship of novel substituted 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylates as potential anti-mycobacterial and anticancer agents

Series of 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives 7a-7zb, 8a-8d and 9a-9d were synthesized and screened for their in vitro anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv (MTB) and cytotoxicity against three human cancer cell lines including A549, SK-N-SH and HeLa. The results indicate that six compounds are more potent and 7za is most effective anti-mycobacterial derivative compared to the standard drugs Ethambutol and Ciprofloxacin. However, 12 compounds exhibited cytotoxicity against human neuroblastoma cell line; amongst them the compound 7v is most effective compared to the standard drug Doxorubicin. This is the first report assigning in vitro anti-mycobacterial, anticancer and structure-activity relationship for this new class of 4H-chromen-1,2,3,4-tetrahydropyrimidine-5- carboxylates.