131020-49-0

Basic information

• Product Name: 4,5,6,7-Tetrahydrobenzimidazole-5-carboxylic acid sulfate
• Synonyms: 4,5,6,7-Tetrahydrobenzimidazole-5-carboxylic acid sulfate;4,5,6,7-Tetrahydro-1H-benzimidazole-6-carboxylic acid sulfate;4,5,6,7-Tetrahydro-1H-benzo[d]imidazole-6-carboxylic acid compound with sulfuric acid (1:1);sulfuric acid,4,5,6,7-tetrahydro-3H-benzimidazole-5-carboxylic acid
• CAS NO: 131020-49-0
• Molecular Formula: C8H10N2O2.H2SO4
• Molecular Weight: 264
• Mol File: 131020-49-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 145-148℃
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4,5,6,7-Tetrahydrobenzimidazole-5-carboxylic acid sulfate(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5,6,7-Tetrahydrobenzimidazole-5-carboxylic acid sulfate(131020-49-0)
• EPA Substance Registry System: 4,5,6,7-Tetrahydrobenzimidazole-5-carboxylic acid sulfate(131020-49-0)

Safety Data

• Hazardous Substances Data: 131020-49-0(Hazardous Substances Data)

Usage

Chemical Properties

Off-white powder

Upstream product

• 15788-16-6 1H-benzimidazole-6-carboxylic acid 
• 619-05-6 3,4-diaminobenzoic acid 

Relevant articles and documents

Synthesis method of Ramosetron

The invention discloses a synthesis method of Ramosetron. According to the method, 3,4-diaminobenzoic acid is used as a starting raw material for finally preparing the Ramosetron through the synthesis of benzimidazole-5-carboxylic acid, benzimidazole-5-methyl carbonate sulfate, 4,5,6,7-tetrahydro benzimidazole-5-methyl carbonate sulfate, 4,5,6,7-tetrahydro benzimidazole-5-triazolylformate sulfate, N-[(4,5,6,7-tetrahydro benzimidazole-5-yl)] pyrrole hydrochloride and 5-[(1-methylindol -3-yl) carbonyl]-4,5,6,7-tetrahydro benzimidazole. Compared with the prior art, the method provided by the invention has the advantages that the reaction conditions are optimized; after the optimization, the reaction is really feasible; the yield of the 4,5,6,7-tetrahydro benzimidazole-5-methyl carbonate sulfate, the 4,5,6,7-tetrahydro benzimidazole-5-triazolylformate sulfate, the N-[(4,5,6,7-tetrahydro benzimidazole-5-yl)] pyrrole hydrochloride and the like is improved; the reaction total yield reaches more than 30 percent; higher economic benefits are realized.