1310218-12-2Relevant academic research and scientific papers
Desymmetrizing asymmetric ring expansion of cyclohexanones with α-diazoacetates catalyzed by chiral aluminum Lewis acid
Hashimoto, Takuya,Naganawa, Yuki,Maruoka, Keiji
, p. 8834 - 8837 (2011/08/03)
Chiral aluminum Lewis acid catalyst composed of Me3Al and 3,3′-bis(trimethylsilyl)-BINOL in a 2:1 ratio was found to promote novel catalytic asymmetric ring expansion of cyclohexanone with α-substituted α-diazoacetates to give seven-membered rings with an all-carbon quaternary center. Application of this strategy to 4-substituted cyclohexanones opened up a novel way for the catalytic desymmetrizing asymmetric construction of cycloheptanones bearing remote α,δ-chiral centers.
