1310218-54-2

Upstream product

• 1310036-71-5 3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzonitrile 
• 1152570-03-0 3-(4-iodo-phenoxymethyl)-benzonitrile 
• 870777-32-5 (4,5-difluoro-2-methoxyphenyl)boronic acid 

Downstream Products

• 1310218-55-3 C₂₅H₂₅F₂NO₄ 
• 1310038-05-1 {[3-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzyl]-methoxycarbonyl-amino}-acetic acid 
• 1310037-69-4 {[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzyl]-isopropoxycarbonyl-amino}-acetic acid 
• 1310037-72-9 {[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzyl]-ethanesulfonyl-amino}-acetic acid 
• 1310038-47-1 {[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzyl]-ethyl-amino}-acetic acid ethyl ester 
• 1310037-55-8 [[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzyl]-(2,2-dimethyl-propionyl)-amino]-acetic acid ethyl ester 
• 1310038-49-3 [3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzylamino]-acetic acid 
• 1310038-45-9 {[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzyl]-ethyl-amino}-acetic acid 
• 1310038-15-3 {[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzyl]-propionyl-amino}-acetic acid 
• 1310037-63-8 {cyclobutanecarbonyl-[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzyl]-amino}-acetic acid 
• 1310037-52-5 [[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzyl]-(2,2-dimethyl-propionyl)-amino]-acetic acid 

Relevant academic research and scientific papers

N-substituted sultam carboxylic acids as novel glycogen synthase activators

Decreased glycogen synthesis and turnover is a common defect in type 2 diabetic patients. Activating glycogen synthase, the enzyme that catalyses the transfer of glucose from UDP-glucose to a glycogen polymer chain, could be a potential therapeutic target for the treatment of diabetes. We discovered a series of N-substituted sultam carboxylic acids as potent glycogen synthase activators. Treatment of human skeletal muscle cells with these compounds resulted in an increase in glycogen synthesis. Compound 4 displayed good oral bioavailability and therefore may be a useful tool molecule to study GS as a potential anti-diabetic target. The Royal Society of Chemistry 2013.