131022-80-5Relevant academic research and scientific papers
Synthesis of 2-Chloro-4,6-di(heteroaryl)pyrimidines
Strekowski, Lucjan,Harden, Donald B.,Grubb, William B.,Patterson, Steven E.,Czarny, Agnieszka,et al.
, p. 1393 - 1400 (2007/10/02)
A practical method for the preparation of 2-chloro-4,6-di(heteroaryl)pyrimidines and their 5-methyl homologues from readily available 2-chloropyrimidine and 2-chloro-5-methylpyrimidine, respectively, is described.The method is based on the addition reactions of heteroaryllithium reagents with chloropyrimidines followed by dehydrogenation of the resultant substituted dihydropyrimidines.The use of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone as the dehydrogenation agent gives the best results.Side reactions in the addition step are discussed.
