131023-24-0

Basic information

• Product Name: H-VAL-ALA-PRO-SER-ASP-SER-ILE-GLN-ALA-GLU-GLU-TRP-TYR-PHE-GLY-LYS-ILE-THR-ARG-ARG-GLU-OH
• Synonyms: PP60V-SRC (137-157);P60 V-SRC (137-157);P60V-SRC 137-157 INHIBITOR PEPTIDE;PEPTIDE A;VAL-ALA-PRO-SER-ASP-SER-ILE-GLN-ALA-GLU-GLU-TRP-TYR-PHE-GLY-LYS-ILE-THR-ARG-ARG-GLU;TYROSINE-SPECIFIC PROTEIN KINASE INHIBITOR;VAPSDSIQAEEWYFGKITRRE;H-VAL-ALA-PRO-SER-ASP-SER-ILE-GLN-ALA-GLU-GLU-TRP-TYR-PHE-GLY-LYS-ILE-THR-ARG-ARG-GLU-OH
• CAS NO: 131023-24-0
• Molecular Formula: C111H168N30O35
• Molecular Weight: 2482.7
• Product Categories: peptide
• Mol File: 131023-24-0.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Density: 1.50±0.1 g/cm3(Predicted)
• Storage Temp.: -15°C
• CAS DataBase Reference: H-VAL-ALA-PRO-SER-ASP-SER-ILE-GLN-ALA-GLU-GLU-TRP-TYR-PHE-GLY-LYS-ILE-THR-ARG-ARG-GLU-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-VAL-ALA-PRO-SER-ASP-SER-ILE-GLN-ALA-GLU-GLU-TRP-TYR-PHE-GLY-LYS-ILE-THR-ARG-ARG-GLU-OH(131023-24-0)
• EPA Substance Registry System: H-VAL-ALA-PRO-SER-ASP-SER-ILE-GLN-ALA-GLU-GLU-TRP-TYR-PHE-GLY-LYS-ILE-THR-ARG-ARG-GLU-OH(131023-24-0)

Safety Data

• Hazardous Substances Data: 131023-24-0(Hazardous Substances Data)

Usage

General Description

The chemical H-VAL-ALA-PRO-SER-ASP-SER-ILE-GLN-ALA-GLU-GLU-TRP-TYR-PHE-GLY-LYS-ILE-THR-ARG-ARG-GLU-OH is a peptide with a sequence of amino acids, starting with valine and ending with a carboxylic acid group. It consists of 20 amino acids and is a potential therapeutic agent due to its ability to interact with biological targets in the body. The specific arrangement of amino acids in this peptide can potentially influence its biological activity, such as its ability to regulate signaling pathways or interact with cellular receptors. further studies and experiments are required to fully understand the physiological effects and potential applications of this chemical.

Relevant articles and documents

Nucleic acids db, the receptor for leptin

The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.

Peptides that stimulate cell survival and axon regeneration

Peptides which consist of or comprise the tetrameric peptide structural unit: Xaa-Xaa-Xaa-Xaa (SEQ.ID.NO.: 1) in which Xaa at position 1 represents Glu or Asp, Xaa at position 2 represents any amino acid, Xaa at position 3 represents any amino acid and Xaa at position 4 represents Glu or Asp, each of the meanings of Xaa being independent, and peptides which consist of or comprise the sequence PYSSTA, particularly when in multimeric form, mimic the beneficial trophic and neuritogenic effects of FGF but lack the undesirable mitogenic effects. They are useful for the treatment of conditions for which FGF has been proposed, including treatment of neurodegenerative diseases, ischaemia, wound healing and stimulation of angiogenesis in cardiac muscle.

Cyclic compounds

The present invention relates to novel Aerothricins represented by the Formula (I), wherein R1, R2, R3, R4, R5, X, Y, Z, and m are as defined in Claim 1; and pharmaceutically acceptable salts thereof. The present invention also relates to a pharmaceutical composition comprising an Aerothricin of the Formula (I) and a pharmaceutically acceptable carrier. Furthermore, the present invention relates to the use of such Aerothricins for the preparation of medicaments, as well as to processes and intermediates for the preparation of the Aerothricins of the Formula (I).