131023-43-3

Basic information

• Product Name: carbazole-1-acetic acid
• Synonyms: carbazole-1-acetic acid
• CAS NO: 131023-43-3
• Molecular Formula: C₁₄H₁₁NO₂
• Molecular Weight: 225.24
• Mol File: 131023-43-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 494.6°Cat760mmHg
• Flash Point: 252.9°C
• Appearance: /
• Density: 1.378g/cm³
• Vapor Pressure: 1.34E-10mmHg at 25°C
• Refractive Index: 1.763
• CAS DataBase Reference: carbazole-1-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: carbazole-1-acetic acid(131023-43-3)
• EPA Substance Registry System: carbazole-1-acetic acid(131023-43-3)

Safety Data

• Hazardous Substances Data: 131023-43-3(Hazardous Substances Data)

Usage

Uses

2-?(9H-?Carbazol-?1-?yl)?acetic Acid is an impurity of Diclofenac (D436450), a nonsteroidal anti-inflammatory compound an decycloxygenase (COX) inhibitor Aceclofenac EP Impurity A

InChI:InChI=1/C14H11NO2/c16-13(17)8-9-4-3-6-11-10-5-1-2-7-12(10)15-14(9)11/h1-7,15H,8H2,(H,16,17)

Upstream product

• 23592-69-0 1-(9H-carbazol-1-yl)ethan-1-one 
• 41428-43-7 carbazole-1-carbonyl chloride 
• 6311-19-9 9H-carbazole-1-carboxylic acid 
• 15307-79-6 diclofenac sodium 
• 855609-35-7 1-carbazol-1-yl-2-diazo-ethanone 
• 854824-06-9 carbazol-1-yl-acetic acid amide 

Relevant articles and documents

Rhodium(III)- and iridium(III)-catalyzed C7 alkylation of indolines with diazo compounds

A RhIII-catalyzed procedure for the C7-selective C-H alkylation of various indolines with a-diazo compounds at room temperature is reported. The advantages of this process are: 1) simple, mild, and pH-neutral reaction conditions, 2) broad substrate scope, 3) complete regioselectivity, 4) no need for an external oxidant, and 5) N2 as the sole byprod-uct. Furthermore, alkylation and bis-alkylation of carbazoles at the C1 and C8 positions have also been developed. More significantly, for the first time, a successful IrIII-catalyzed inter-molecular insertion of arene C-H bonds into a-diazo compounds is reported.