1310328-65-4

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 558-13-4 carbon tetrabromide 
• 96013-95-5 3-(tert-butyl-dimethyl-sylanyloxy)benzaldehyde 

Downstream Products

• 1310328-61-0 2-{6-[3-(tert-butyldimethylsilanyloxy)phenyl]-2,3-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl}-propan-2-ol 
• 1310328-30-3 3-[6-(1-hydroxy-1-methylethyl)-5,6-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl]phenol 
• 163233-08-7 m-(tert-butyldimethylsiloxy)phenylacetylene 

Relevant academic research and scientific papers

HIF-1α inhibitors: Synthesis and biological evaluation of novel moracin O and P analogues

The natural products moracins O and P exhibited potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia. Systematic variations of the structures of benzofuran type moracins were made and structure-activity relationship analysis showed the importance of the 2-arylbenzofuran ring and the (R)-configuration of the core scaffold. Further evaluation of the representative compound 5 showed its inhibitory effect on HIF-1α protein accumulation and target gene expression under hypoxia.