1310357-40-4

Basic information

• Product Name: (±)-7-chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol
• CAS NO: 1310357-40-4
• Molecular Weight: 197.664
• Mol File: 1310357-40-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (±)-7-chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (±)-7-chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol(1310357-40-4)
• EPA Substance Registry System: (±)-7-chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol(1310357-40-4)

Safety Data

• Hazardous Substances Data: 1310357-40-4(Hazardous Substances Data)

Usage

General Description

(±)-7-chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol is a chemical compound that belongs to the class of azepines. It is a derivative of the tricyclic antidepressant imipramine and possesses both antidepressant and antianxiety properties. The compound is a white to off-white crystalline powder that is soluble in water and ethanol. It acts as a serotonin-norepinephrine reuptake inhibitor, leading to increased levels of these neurotransmitters in the brain. This can result in improved mood and reduced feelings of anxiety. The compound has potential therapeutic applications in the treatment of depression and anxiety disorders.

Upstream product

• 160129-45-3 7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one 

Relevant articles and documents

Methylene-Linked Bis-NHC Half-Sandwich Ruthenium Complexes: Binding of Small Molecules and Catalysis toward Ketone Transfer Hydrogenation

The complex [Cp*RuCl(COD)] reacts with LH2Cl2 (L = bis(3-methylimidazol-2-ylidene)) and LiBun in tetrahydrofuran at 65 °C furnishing the bis-carbene derivative [Cp*RuCl(L)] (2). This compound reacts with NaBPh4 in MeOH under dinitrogen to yield the labile dinitrogen-bridged complex [{Cp*Ru(L)}2(μ-N2)][BPh4]2 (4). The dinitrogen ligand in 4 is readily replaced by a series of donor molecules leading to the corresponding cationic complexes [Cp*Ru(X)(L)][BPh4] (X = MeCN 3, H2 6, C2H4 8a, CH2CHCOOMe 8b, CHPh 9). Attempts to recrystallize 4 from MeNO2/EtOH solutions led to the isolation of the nitrosyl derivative [Cp*Ru(NO)(L)][BPh4]2 (5), which was structurally characterized. The allenylidene complex [Cp*Ru═C═C═CPh2(L)][BPh4] (10) was also obtained, and it was prepared by reaction of 2 with HCCC(OH)Ph2 and NaBPh4 in MeOH at 60 °C. Complexes 3, 4, and 6 are efficient catalyst precursors for the transfer hydrogenation of a broad range of ketones. The dihydrogen complex 6 has proven particularly effective, reaching TOF values up to 455 h-1 at catalyst loadings of 0.1% mol, with a high functional group tolerance on the reduction of a broad scope of aryl and aliphatic ketones to yield the corresponding alcohols.