1310383-27-7 Usage
Description
4-(1-Methyl-1H-imidazol-2-yl)phenylboronic acid is a chemical compound that belongs to the class of phenylboronic acids, characterized by a boronic acid functional group attached to a phenyl group with a heterocyclic imidazole ring. This unique structure endows it with versatile reactivity and stability, making it a valuable tool in organic synthesis and a promising candidate for pharmaceutical and agrochemical development.
Uses
Used in Organic Synthesis:
4-(1-Methyl-1H-imidazol-2-yl)phenylboronic acid is used as a reagent in organic chemistry reactions for the formation of carbon-carbon or carbon-heteroatom bonds. Its ability to participate in various coupling reactions and form stable intermediates makes it an essential component in the synthesis of complex organic molecules.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 4-(1-Methyl-1H-imidazol-2-yl)phenylboronic acid is used as a key intermediate in the synthesis of drug candidates. Its capacity to form stable complexes with diols and other nucleophiles allows for the creation of new bioactive molecules with potential therapeutic applications.
Used in Agrochemical Development:
Similarly, in agrochemicals, 4-(1-Methyl-1H-imidazol-2-yl)phenylboronic acid is utilized as a building block for the development of novel compounds with pesticidal or herbicidal properties. Its reactivity and stability contribute to the design of effective and environmentally friendly agrochemicals.
Overall, the diverse applications of 4-(1-Methyl-1H-imidazol-2-yl)phenylboronic acid across different industries highlight its importance and potential in the fields of organic synthesis, pharmaceuticals, and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 1310383-27-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,1,0,3,8 and 3 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1310383-27:
(9*1)+(8*3)+(7*1)+(6*0)+(5*3)+(4*8)+(3*3)+(2*2)+(1*7)=107
107 % 10 = 7
So 1310383-27-7 is a valid CAS Registry Number.
1310383-27-7Relevant articles and documents
Installation of Minimal Tetrazines through Silver-Mediated Liebeskind-Srogl Coupling with Arylboronic Acids
Lambert, William D.,Fang, Yinzhi,Mahapatra, Subham,Huang, Zhen,Am Ende, Christopher W.,Fox, Joseph M.
, p. 17068 - 17074 (2019)
Described is a general method for the installation of a minimal 6-methyltetrazin-3-yl group via the first example of a Ag-mediated Liebeskind-Srogl cross-coupling. The attachment of bioorthogonal tetrazines on complex molecules typically relies on linkers that can negatively impact the physiochemical properties of conjugates. Cross-coupling with arylboronic acids and a new reagent, 3-((p-biphenyl-4-ylmethyl)thio)-6-methyltetrazine (b-Tz), proceeds under mild, PdCl2(dppf)-catalyzed conditions to introduce minimal, linker-free tetrazine functionality. Safety considerations guided our design of b-Tz which can be prepared on decagram scale without handling hydrazine and without forming volatile, high-nitrogen tetrazine byproducts. Replacing conventional Cu(I) salts used in Liebeskind-Srogl cross-coupling with a Ag2O mediator resulted in higher yields across a broad library of aryl and heteroaryl boronic acids and provides improved access to a fluorogenic tetrazine-BODIPY conjugate. A covalent probe for MAGL incorporating 6-methyltetrazinyl functionality was synthesized in high yield and labeled endogenous MAGL in live cells. This new Ag-mediated cross-coupling method using b-Tz is anticipated to find additional applications for directly introducing the tetrazine subunit to complex substrates.
